hrp0089p2-p074 | Diabetes & Insulin P2 | ESPE2018

The Application of Next Generation Sequencing Mody Gene Panel in Greek Patients

Tatsi Elizabeth , Smirnaki Penelopi , Triantafilou Panagiota , Tsiroukidou Kyriaki , Kotsa Kalliopi , Lambadiari Vaia , Chrousos George , Kanaka-Gantenbein Christina , Sertedaki Amalia

Background: Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD). It is characterized by early onset, autosomal dominant inheritance and a defect in β cell insulin secretion. To date 14 different MODY subtypes have been reported each one with a distinct genetic aetiology. However four are the most common subtypes, namely MODY 1 (HNF4A), MODY2 (GCK), MODY3 (HNF1A), MODY...